Sass, F., T. Ma, J.H. Ekberg, M. Kirigiti, M.G. Ureña, L. Dollet, J.M. Brown, A.L. Basse, W.T. Yacawych, H.B. Burm, M.K. Andersen, T.S. Nielsen, A.J. Tomlinson, O. Dmytiyeva, D.P. Christensen, L. Bader, C.T. Vo, Y. Wang, D.M. Rausch, C.K. Kristensen, M. Gestal-Mato, W.I.H. Panhuis, K.A. Sjøberg, S. Kernodle, J.E. Petersen, A. Pavlovskyi, M. Sandhu, I. Moltke, M.E. Jørgensen, A. Albrechtsen, N. Grarup, M.M. Babu, P.C.N. Rensen, S. Kooijman, R.J. Seeley, A. Worthmann, J. Heeren, T.H. Pers, T. Hansen, M.B.F. Gustafsson, M. Tang-Christensen, T.O. Kilpeläinen, M.G. Myers Jr, P. Kievit, T.W. Schwartz, J.B. Hansen, and Z. Gerhart-Hines:
“NK2R control of energy expenditure and feeding to treat metabolic diseases.”
Nature, 2024; Nov;635(8040):987-1000. (PubMed)
Basse, A.L., K.N. Nielsen, I. Karavaeva, L.R. Ingerslev, T. Ma, J.F. Havelund, T.S. Nielsen, M. Frost, J. Peics, E. Dalbram, M. Dall, J.R. Zierath, R. Barres, N.J. Faergeman, J.T. Treebak and Z. Gerhart-Hines:
"NAMPT-dependent NAD(+) biosynthesis controls circadian metabolism in a tissue-specific manner."
Proc Natl Acad Sci U S A, 2023; 120(14): e2220102120. (PubMed)
Peluso, A.A., A.T. Lundgaard, P. Babaei, F. Mousovich-Neto, A.L. Rocha, M.V. Damgaard, E.G. Bak, T. Gnanasekaran, O.L. Dollerup, S.A.J. Trammell, T.S. Nielsen, T. Kern, C.B. Abild, K. Sulek, T. Ma, Z. Gerhart-Hines, M.P. Gillum, M. Arumugam, C. Orskov, D. McCloskey, N. Jessen, M.J. Herrgard, M.A.S. Mori and J.T. Treebak:
"Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans."
NPJ Aging, 2023; 9(1): 7. (PubMed)
Damgaard, M.V., T.S. Nielsen, A.L. Basse, S. Chubanava, K. Trost, T. Moritz, R.W. Dellinger, S. Larsen and J.T. Treebak:
"Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD(+) without impacting respiratory capacity or insulin sensitivity."
iScience, 2022; 25(2): 103863. (PubMed)
Tozzi, M., E.L. Brown, P.S.S. Petersen, M. Lundh, M.S. Isidor, K. Plucinska, T.S. Nielsen, M. Agueda-Oyarzabal, L. Small, J.T. Treebak and B. Emanuelli:
"Dynamic interplay between Afadin(S1795) phosphorylation and diet regulates glucose homeostasis in obese mice."
J Physiol, 2022; 600(4): 885-902. (PubMed)
Dall, M., A.S. Hassing, L. Niu, T.S. Nielsen, L.R. Ingerslev, K. Sulek, S.A.J. Trammell, M.P. Gillum, R. Barres, S. Larsen, S.S. Poulsen, M. Mann, C. Orskov and J.T. Treebak:
"Hepatocyte-specific perturbation of NAD(+) biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes."
J Biol Chem, 2021; 297(6): 101388. (PubMed)
Gonzalez-Franquesa, A., B. Stocks, M.L. Borg, M. Kuefner, E. Dalbram, T.S. Nielsen, A. Agrawal, S. Pankratova, A.V. Chibalin, H.K.R. Karlsson, S. Gheibi, M. Bjornholm, N.R. Jorgensen, C. Clemmensen, M. Hostrup, J.T. Treebak, A. Krook, J.R. Zierath and A.S. Deshmukh:
"Discovery of thymosin beta4 as a human exerkine and growth factor."
Am J Physiol Cell Physiol, 2021; 321(5): C770-C778. (PubMed)
Sveidahl Johansen, O., T. Ma, J.B. Hansen, L.K. Markussen, R. Schreiber, L. Reverte-Salisa, H. Dong, D.P. Christensen, W. Sun, T. Gnad, I. Karavaeva, T.S. Nielsen, S. Kooijman, C. Cero, O. Dmytriyeva, Y. Shen, M. Razzoli, S.L. O'Brien, E.N. Kuipers, C.H. Nielsen, W. Orchard, N. Willemsen, N.Z. Jespersen, M. Lundh, E.G. Sustarsic, C.M. Hallgren, M. Frost, S. McGonigle, M.S. Isidor, C. Broholm, O. Pedersen, J.B. Hansen, N. Grarup, T. Hansen, A. Kjaer, J.G. Granneman, M.M. Babu, D. Calebiro, S. Nielsen, M. Ryden, R. Soccio, P.C.N. Rensen, J.T. Treebak, T.W. Schwartz, B. Emanuelli, A. Bartolomucci, A. Pfeifer, R. Zechner, C. Scheele, S. Mandrup and Z. Gerhart-Hines:
"Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis."
Cell, 2021; 184(13): 3502-3518 e3533. (PubMed)
Lubberding, A.F., J. Zhang, M. Lundh, T.S. Nielsen, M.S. Sondergaard, M. Villadsen, E.Z. Skovhoj, G.A. Boer, J.B. Hansen, M.B. Thomsen, J.T. Treebak, J.J. Holst, J.K. Kanters, T. Mandrup-Poulsen, T. Jespersen, B. Emanuelli and S.S. Torekov:
"Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V."
Sci Rep, 2021; 11(1): 12253. (PubMed)
Grevengoed, T.J., S.A. Trammell, J.S. Svenningsen, M.V. Makarov, T.S. Nielsen, J.C.B. Jacobsen, J.T. Treebak, P.C. Calder, M.E. Migaud, B.F. Cravatt and M.P. Gillum:
"An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides."
J Clin Invest, 2021; 131(6). (PubMed)
Brandao, B.B., S. Madsen, A. Rabiee, M. Oliverio, G.P. Ruiz, D.L. Ferrucci, J.L. Branquinho, D. Razolli, S. Pinto, T.S. Nielsen, W.T. Festuccia, A.S. Martins, B.A. Guerra, T.L. Knittel, D. Sogaard, S. Larsen, J.W. Helge, J. Brandauer, L.A. Velloso, B. Emanuelli, J.W. Kornfeld, C.R. Kahn, S.G. Vienberg, J.R. Zierath, J.T. Treebak and M.A. Mori:
"Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise."
Proc Natl Acad Sci U S A, 2020; 117(38): 23932-23941. (PubMed)
Ramshanker, N., N. Jessen, T.S. Voss, S.B. Pedersen, J.O.L. Jorgensen, T.S. Nielsen, J. Frystyk and N. Moller:
"Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans."
Metabolism, 2019; 99: 1-10. (PubMed)
Faarkrog Hoyer, K., C. Laustsen, S. Ringgaard, H. Qi, C.O. Mariager, T.S. Nielsen, U.K. Sundekilde, J.T. Treebak, N. Jessen and H. Stodkilde-Jorgensen:
"Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS."
J Endocrinol, 2019; 242(3): 251-260. (PubMed)
De Guia, R. M., M. Agerholm, T.S. Nielsen, L.A. Consitt, D. Sogaard, J.W. Helge, S. Larsen, J. Brandauer, J.A. Houmard and J.T. Treebak:
"Aerobic and resistance exercise training reverses age-dependent decline in NAD(+) salvage capacity in human skeletal muscle."
Physiol Rep, 2019; 7(12): e14139. (PubMed)
Voss, T.S., M.H. Vendelbo, U. Kampmann, S.B. Pedersen, T.S. Nielsen, M. Johannsen, M.V. Svart, N. Jessen and N. Moller:
"Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after insulin withdrawal and subsequent insulin therapy to model the initiating steps of ketoacidosis."
Diabetologia, 2019; 62(3): 494-503. (PubMed)
Park, S., K.D. Turner, D. Zheng, J.J. Brault, K. Zou, A.B. Chaves, T.S. Nielsen, C. J. Tanner, J.T. Treebak and J.A. Houmard:
"Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals."
J Physiol, 2019; 597(2): 449-466. (PubMed)
Sharma, V.M., E.T. Vestergaard, N. Jessen, P. Kolind-Thomsen, B. Nellemann, T.S. Nielsen, M.H. Vendelbo, N. Moller, R. Sharma, K. Y. Lee, J.J. Kopchick, J.O.L. Jorgensen and V. Puri:
"Growth hormone acts along the PPARgamma-FSP27 axis to stimulate lipolysis in human adipocytes."
Am J Physiol Endocrinol Metab, 2019; 316(1): E34-E42. (PubMed)
Hoyer, K.F., T.S. Nielsen, S. Risis, J.T. Treebak and N. Jessen:
"Sevoflurane Impairs Insulin Secretion and Tissue-Specific Glucose Uptake In Vivo."
Basic Clin Pharmacol Toxicol, 2018; 123(6): 732-738. (PubMed)
Shi, H., A. Munk, T.S. Nielsen, M.R. Daughtry, L. Larsson, S. Li, K.F. Hoyer, H.W. Geisler, K. Sulek, R. Kjobsted, T. Fisher, M.M. Andersen, Z. Shen, U.K. Hansen, E.M. England, Z. Cheng, K. Hojlund, J.F.P. Wojtaszewski, X. Yang, M.W. Hulver, R.F. Helm, J.T. Treebak and D.E. Gerrard:
"Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity."
Mol Metab, 2018; 11: 160-177. (PubMed)
Voss, T.S., M.H. Vendelbo, U. Kampmann, S.B. Pedersen, T.S. Nielsen, M. Johannsen, M.V. Svart, N. Jessen and N. Moller:
"Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study."
Diabetologia, 2017; 60(1): 143-152. (PubMed)
Jensen, B.A., T.S. Nielsen, A.M. Fritzen, J.B. Holm, E. Fjaere, A.K. Serup, K. Borkowski, S. Risis, S. I. Paerregaard, I. Sogaard, A. Poupeau, M. Poulsen, T. Ma, C. Sina, B. Kiens, L. Madsen, K. Kristiansen and J.T. Treebak:
"Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain."
Metabolism, 2016; 65(12): 1706-1719. (PubMed)
Bach, E., A.B. Moller, J.O. Jorgensen, M.H. Vendelbo, N. Jessen, S.B. Pedersen, T.S. Nielsen and N. Moller:
”Stress hormone release is a key component of the metabolic response to lipopolysaccharide: studies in hypopituitary and healthy subjects.”
Eur J Endocrinol, 2016; 175(5): 455-465. (PubMed)
Rittig, N., E. Bach, H.H. Thomsen, S.B. Pedersen, T.S. Nielsen, J.O. Jorgensen, N. Jessen and N. Moller:
"Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial."
PLoS One, 2016; 11(9): e0162167. (PubMed)
Bak, A.M., A.B. Moller, M.H. Vendelbo, T.S. Nielsen, R. Viggers, J. Rungby, S.B. Pedersen, J.O. Jorgensen, N. Jessen and N. Moller:
”Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast.”
Am J Physiol Endocrinol Metab, 2016; 311(1): E224-235. (PubMed)
Svart, M., U. Kampmann, T. Voss, S.B. Pedersen, M. Johannsen, N. Rittig, P.L. Poulsen, T.S. Nielsen, N. Jessen and N. Moller:
"Combined Insulin Deficiency and Endotoxin Exposure Stimulate Lipid Mobilization and Alter Adipose Tissue Signaling in an Experimental Model of Ketoacidosis in Subjects With Type 1 Diabetes: A Randomized Controlled Crossover Trial."
Diabetes, 2016; 65(5): 1380-1386. (PubMed)
Jessen, N., T.S. Nielsen, M.H. Vendelbo, R. Viggers, O.G. Stoen, A. Evans and O. Frobert:
"Pronounced expression of the lipolytic inhibitor G0/G1 Switch Gene 2 (G0S2) in adipose tissue from brown bears (Ursus arctos) prior to hibernation."
Physiol Rep, 2016; 4(8). (PubMed)
Bach, E., A.B. Moller, J.O. Jorgensen, M.H. Vendelbo, N. Jessen, J.F. Olesen, S.B. Pedersen, T.S. Nielsen and N. Moller:
”Intact pituitary function is decisive for the catabolic response to TNF-alpha: studies of protein, glucose and fatty acid metabolism in hypopituitary and healthy subjects.”
J Clin Endocrinol Metab, 2015; 100(2): 578-586. (PubMed)
Moltke, I., N. Grarup, M.E. Jorgensen, P. Bjerregaard, J.T. Treebak, M. Fumagalli, T.S. Korneliussen, M.A. Andersen, T.S. Nielsen, N.T. Krarup, A.P. Gjesing, J.R. Zierath, A. Linneberg, X. Wu, G. Sun, X. Jin, J. Al-Aama, J. Wang, K. Borch-Johnsen, O. Pedersen, R. Nielsen, A. Albrechtsen and T. Hansen:
"A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes."
Nature, 2014; 512(7513): 190-193. (PubMed)
Nielsen, T.S., N. Jessen, J.O. Jorgensen, N. Moller and S. Lund:
"Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease."
J Mol Endocrinol, 2014; 52(3): R199-222. (PubMed)
Nielsen, T.S. and N. Moller:
"Adipose triglyceride lipase and G0/G1 switch gene 2: approaching proof of concept."
Diabetes, 2014; 63(3): 847-849. (PubMed)
Nellemann, B., M.H. Vendelbo, T.S. Nielsen, A. M. Bak, M. Hogild, S.B. Pedersen, R.S. Bienso, H. Pilegaard, N. Moller, N. Jessen and J.O. Jorgensen:
"Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity."
Acta Physiol, 2014; (Oxf) 210(2): 392-402. (PubMed)
Nielsen, T.S., U. Kampmann, R.R. Nielsen, N. Jessen, L. Orskov, S.B. Pedersen, J.O. Jorgensen, S. Lund and N. Moller:
"Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes."
J Clin Endocrinol Metab, 2012; v97(7): E1348-1352. (PubMed)
Christensen, B., C. Lundby, N. Jessen, T.S. Nielsen, P.F. Vestergaard, N. Moller, H. Pilegaard, S.B. Pedersen, J.J. Kopchick and J.O. Jorgensen:
"Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects."
PLoS One, 2012; 7(2): e31857. (PubMed)
Vendelbo, M.H., B.F. Clasen, J.T. Treebak, L. Moller, T. Krusenstjerna-Hafstrom, M. Madsen, T.S. Nielsen, H. Stodkilde-Jorgensen, S.B. Pedersen, J.O. Jorgensen, L.J. Goodyear, J.F. Wojtaszewski, N. Moller and N. Jessen:
"Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle."
Am J Physiol Endocrinol Metab, 2012; 302(2): E190-200. (PubMed)
Kampmann, U., B. Christensen, T.S. Nielsen, S.B. Pedersen, L. Orskov, S. Lund, N. Moller and N. Jessen:
"GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance."
PLoS One, 2011; 6(11): e27854. (PubMed)
Nielsen, T.S., M.H. Vendelbo, N. Jessen, S.B. Pedersen, J.O. Jorgensen, S. Lund and N. Moller:
"Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue."
J Clin Endocrinol Metab, 2011; 96(8): E1293-1297. (PubMed)
Jorgensen, J.O., K.Z. Rubeck, T.S. Nielsen, B.F. Clasen, M. Vendelboe, T.K. Hafstrom, M. Madsen and S. Lund:
"Effects of GH in human muscle and fat."
Pediatr Nephrol, 2010; 25(4): 705-709. (PubMed)
Bennetzen, M.F., T.S. Nielsen, S.K. Paulsen, J. Bendix, S. Fisker, N. Jessen, S. Lund, B. Richelsen and S.B. Pedersen:
"Reduced cannabinoid receptor 1 protein in subcutaneous adipose tissue of obese."
Eur J Clin Invest, 2010; 40(2): 121-126. (PubMed)
I’m always excited to connect with like-minded professionals who are looking to advance preclinical in vivo research or need expert guidance on navigating the complexities of advanced in vivo methodologies.
